Stem cells for Asthma
What is Asthma?
Asthma is a chronic disease that affects your airways. Your airways are tubes that carry air in and out of your lungs. If you have asthma, the inside walls of your airways become sore and swollen. That makes them very sensitive, and they may react strongly to things that you are allergic to or find irritating.
When your airways react, they get narrower and your lungs get less air. This can cause wheezing, coughing, chest tightness, and trouble breathing, especially early in the morning or at night.When your asthma symptoms become worse than usual, it’s called an asthma attack. In a severe asthma attack, the airways can close so much that your vital organs do not get enough oxygen. People can die from severe asthma attacks.
Who can get Asthma?
People get asthma because of an interaction between the environment in which they live and the genes they inherit.
1)Allergies: Most people with asthma have allergies. Your response to allergens—proteins from common materials like house dust mites, cockroaches, and pollens—may cause the inflammation that leads to asthma symptoms. Researchers are studying methods for reducing allergen levels to prevent inflammation.
For example, many inner-city children are allergic to cockroaches and experience severe asthma. Reducing cockroach allergens and tobacco smoke in inner-city homes may help.
2)Environment: Researchers now suspect that susceptibility to asthma develops very early in life. A pregnant woman’s cigarette smoking, exposures to allergens, and diet may play a role. Children’s exposures to allergens and respiratory infections during the first three years of life may make them more likely to develop asthma.
3)Genetics: Genes also play a role in the development of asthma. Researchers are studying families in different ethnic and geographic communities to identify which genes are related to asthma. Genetic studies have also revealed differences in the ways patients respond to medications. Understanding the genetics of asthma should provide clues to preventing the disease and help physicians select the most effective treatments for individual patients.Asthma affects an estimated 300 million people worldwide and caused 250,000 deaths in 2009.
Mesenchymal stem cells have the commonality of stem cells for self-replication and differentiation, and can be used as seed cells for a variety of tissue engineering. Mesenchymal stem cells can differentiate into lung, tracheal, muscle, nerve, blood vessels and other directions at different stages of development and under specific environmental conditions.
Therapeutic mechanism of mesenchymal stem cells
1. Mesenchymal stem cells can be customized and differentiated into damaged tissue cells.
2. Mesenchymal stem cells improve disease by mitochondrial metastasis and promotion of endogenous stem cell proliferation and chemotaxis.
3. Mesenchymal stem cells have immunomodulatory effects and mediate immunosuppression by secreting soluble factors and small molecule chemicals.
Airway inflammation allows the mesenchymal stem cells to be recruited and colonized in the damaged airway epithelium;
-Mesenchymal stem cells relieve airway inflammation by regulating the balance of Th1 / Th2;
-Mesenchymal stem cells regulate airway inflammation by direct or indirect regulation of airway inflammation;
-Mesenchymal stem cells can suppress the immune response of immune cells through a series of soluble factors, reduce or even terminate the inflammatory inflammation of airway inflammation;
-Mesenchymal stem cells can inhibit airway inflammation by up-regulating CD4 + CD25 + regulatory T cells.